Cancer: Experiments and Concepts

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Gao, D. Organoid development in cancer genome discovery. Heid, I.

  1. Surface Markers for the Identification of Cancer Stem Cells.
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Co-clinical assessment of tumor cellularity in pancreatic cancer. Kopetz, S. The promise of patient-derived xenografts: the best laid plans of mice and men. Christie, A. T-cell lymphoma patient-derived xenografts and newly developed cell lines recapitulate aspects of disease biology and represent novel tools for preclinical drug development. Blood , Ye, W. Quantitative evaluation of the immunodeficiency of a mouse strain by tumor engraftments. Morton, C. Establishment of human tumor xenografts in immunodeficient mice.

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Stem Cells 16 , — Arango, N. Selinexor KPT demonstrates anti-tumor efficacy in preclinical models of triple-negative breast cancer. Breast Cancer Res. Makita, Y. Antitumor activity of kinetochore-associated protein 2 siRNA against lung cancer patient-derived tumor xenografts. Kissel, M. Antitumor effects of regorafenib and sorafenib in preclinical models of hepatocellular carcinoma.


Oncotarget 8 , — Validation of a preclinical model for assessment of drug efficacy in melanoma. Oncotarget 7 , — Gu, Z. Evaluation of the correlations between patient-derived xenograft PDX model-based mouse trials and cancer patient-based clinical trials. Bertotti, A. Cancer Discov. Sivanand, S. A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma. Das Thakur, M.

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Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance. Sebastiani, V. Immunohistochemical and genetic evaluation of deoxycytidine kinase in pancreatic cancer: relationship to molecular mechanisms of gemcitabine resistance and survival. Hidalgo, M.

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Patient-derived xenograft models: an emerging platform for translational cancer research. Owonikoko, T. Patient-derived xenografts faithfully replicated clinical outcome in a phase II co-clinical trial of arsenic trioxide in relapsed small cell lung cancer. Kim, H. Co-clinical trials demonstrate predictive biomarkers for dovitinib, an FGFR inhibitor, in lung squamous cell carcinoma.

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Generation of improved mouse models for the study of hepatitis C virus. Pearson, T. Chapter 15, Unit 15 Magnotti, E. The latest animal models of ovarian cancer for novel drug discovery. Expert Opin. Drug Discov.

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Humanized hemato-lymphoid system mice. Haematologica , 5—19 Herndler-Brandstetter, D. Humanized mouse model supports development, function, and tissue residency of human natural killer cells. USA , E—E Muenst, S. The immune system and cancer evasion strategies: therapeutic concepts. Sun, Y. Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B. Shiga, K.


Cancer-associated fibroblasts: their characteristics and their roles in tumor growth. Cancers Basel 7 , — Morton, J. XactMice: humanizing mouse bone marrow enables microenvironment reconstitution in a patient-derived xenograft model of head and neck cancer.

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Oncogene 35 , — Chang, D. Human anti-CAIX antibodies mediate immune cell inhibition of renal cell carcinoma in vitro and in a humanized mouse model in vivo. Cancer 14 , Akiyama, Y. The anti-tumor activity of the STAT3 inhibitor STX occurs via promotion of tumor-infiltrating lymphocyte accumulation in temozolomide-resistant glioblastoma cell line. Zheng, B. PD-1 axis expression in musculoskeletal tumors and antitumor effect of nivolumab in osteosarcoma model of humanized mouse. Hu, Z. Human melanoma immunotherapy using tumor antigen-specific T cells generated in humanized mice. Tsoneva, D.

Humanized mice with subcutaneous human dolid tumors for immune response analysis of vaccinia virus-mediated oncolysis. Oncolytics 5 , 41—61 Jespersen, H. Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse model.