Next-Generation Therapies and Technologies for Immune-Mediated Inflammatory Diseases

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Normal luminal bacteria predictably and uniformly induce chronic colonic, gastric and systemic inflammation in B27 transgenic F rats, but all bacterial species do not have equal activities. Go to JCI Insight. Citations to this article. View: Text PDF. Category: Research Article. Text PDF. Loading citation information Sign up for email alerts. Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients.

Hartemann, A. Lancet Diabetes Endocrinol. Trotta, E. A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism. Sockolosky, J. Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes. This study reports the generation of an orthogonal IL-2—IL-2 receptor pair that could be used to trigger IL-2 signalling specifically in infused engineered T reg cells.

Furukawa, A. Impact of immune-modulatory drugs on regulatory T cell. Transplantation , — Transplant trials with Tregs: perils and promises.

Landwehr-Kenzel, S. Ex vivo expanded natural regulatory T cells from patients with end-stage renal disease or kidney transplantation are useful for autologous cell therapy. Kidney Int. Green, E. Immunity 16 , — This article demonstrates that small numbers 2, cells of pancreatic antigen-specific T reg cells exposed to TNF receptor signalling in vivo can prevent autoimmune diabetes in mice. Huang, J. Bluhm, J. Elhanati, Y. Predicting the spectrum of TCR repertoire sharing with a data-driven model of recombination. Klein, L. Jordan, M.

Malchow, S. Aire enforces immune tolerance by directing autoreactive T cells into the regulatory T cell lineage. Immunity 44 , — Anderson, M. Projection of an immunological self shadow within the thymus by the Aire protein. Hsieh, C. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires.

Building on a Foundation of Strength

Leonard, J. Immunity 47 , — e Yang, M. Cutting edge: processing of oxidized peptides in macrophages regulates T cell activation and development of autoimmune arthritis. Moss, C. Asparagine deamidation perturbs antigen presentation on class II major histocompatibility complex molecules. Valesini, G. Citrullination and autoimmunity. Patterson, H. Protein kinase inhibitors in the treatment of inflammatory and autoimmune diseases. Delong, T.

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Diabetogenic T-cell clones recognize an altered peptide of chromogranin A. Diabetes 61 , — McGinty, J. T cell epitopes and post-translationally modified epitopes in type 1 diabetes. Jin, N. N-terminal additions to the WE14 peptide of chromogranin A create strong autoantigen agonists in type 1 diabetes. Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion. This article shows that some diabetogenic T cells recognize epitopes formed by fusion of proinsulin peptides to other peptides that are found in the secretory vesicles of beta cells. Liu, Z. Immune homeostasis enforced by co-localized effector and regulatory T cells.

Moran, A.

Next-generation regulatory T cell therapy | Nature Reviews Drug Discovery

T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. Spence, A. Revealing the specificity of regulatory T cells in murine autoimmune diabetes. Wei, X. Reciprocal expression of IL and IL defines two distinct effector Treg subsets that are required for maintenance of immune tolerance.

Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes. JCI Insight 1 , e Howie, B. High-throughput pairing of T cell receptor alpha and beta sequences. Glanville, J.

Biologics Across Immune Mediated Inflammatory Disease from the Rheumatology Perspective

Identifying specificity groups in the T cell receptor repertoire. Nature , 94—98 Dash, P. Quantifiable predictive features define epitope-specific T cell receptor repertoires.

Nature , 89—93 Dembic, Z. Transfer of specificity by murine alpha and beta T-cell receptor genes. Tsang, J. Wright, G. Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis.

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Cohen, C. Enhanced antitumor activity of T cells engineered to express T-cell receptors with a second disulfide bond. Cancer Res. Kuball, J.

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Facilitating matched pairing and expression of TCR chains introduced into human T cells. Sommermeyer, D. Bialer, G. Selected murine residues endow human TCR with enhanced tumor recognition.

Inflammation: Natural Resources and Its Applications

Uckert, W. Cancer Immunol. Torikai, H. A foundation for universal T-cell based immunotherapy: T cells engineered to express a CDspecific chimeric-antigen-receptor and eliminate expression of endogenous TCR. Roth, T. Reprogramming human T cell function and specificity with non-viral genome targeting. Govers, C. Walseng, E. A TCR-based chimeric antigen receptor.